腸菌移植（FMT）聯(lián)合化療，提高抗癌有效率

2.腸道菌群可以改善Th1和Th17的數(shù)量，提升腫瘤浸潤淋巴細(xì)胞功能和CD8+細(xì)胞毒性T細(xì)胞亞群的機制，從而增強了化療藥物環(huán)磷酰胺的抗腫瘤作用。

3.腸道菌群可以緩解化療藥物導(dǎo)致的腦部炎癥，提高癌癥患者生存質(zhì)量；

4.腸道菌群移植可以調(diào)整腸道菌群可以降低血管毒性，改善腸道免疫屏障的破壞，結(jié)合化療，可以提高癌癥治療效率。

參考文獻(xiàn)：

[1]B. R. Loman,K. R. Jordan,B. Haynes,M. T. Bailey,L. M. Pyter. Chemotherapy-induced neuroinflammation is associated with disrupted colonic and bacterial homeostasis in female mice[J]. Scientific Reports,2019,9(2):

[2]Iida Noriho,Dzutsev Amiran,Stewart C. Andrew,Smith Loretta,Bouladoux Nicolas,Weingarten Rebecca A.,Molina Daniel A.,Salcedo Rosalba,Back Timothy,Cramer Sarah,Dai RenMing,Kiu Hiu,Cardone Marco,Naik Shruti,Patri Anil K.,Wang Ena,Marincola Francesco M.,Frank Karen M.,Belkaid Yasmine,Trinchieri Giorgio,Goldszmid Romina S.. Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment[J]. Science,2013,342(6161):

[3]Di-Wei Zheng,Xue Dong,Pei Pan,Ke-Wei Chen,Jin-Xuan Fan,Si-Xue Cheng,Xian-Zheng Zhang. Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy[J]. Nature Biomedical Engineering,2019,3(9):

[4]Ma Weidong,Mao Qixing,Xia Wenjie,Dong Gaochao,Yu Changhua,Jiang Feng. Gut Microbiota Shapes the Efficiency of Cancer Therapy.[J]. Frontiers in microbiology,2019,10:

[5]Muhammad Bilal Abid. Could the menagerie of the gut microbiome really cure cancer? Hope or hype[J]. BioMed Central,2019,7(1):

[6]Yoshitaro Heshiki,Ruben Vazquez-Uribe,Jin Li,Yueqiong Ni,Scott Quainoo,Lejla Imamovic,Jun Li,Maria S?rensen,Billy K. C. Chow,Glen J. Weiss,Aimin Xu,Morten O. A. Sommer,Gianni Panagiotou. Predictable modulation of cancer treatment outcomes by the gut microbiota[J]. Microbiome,2020,8(6371):

[7]Alexander James L,Wilson Ian D,Teare Julian,Marchesi Julian R,Nicholson Jeremy K,Kinross James M. Gut microbiota modulation of chemotherapy efficacy and toxicity.[J]. Nature reviews. Gastroenterology & hepatology,2017,14(6):

[8]Lee MongHong. Harness the functions of gut microbiome in tumorigenesis for cancer treatment.[J]. Cancer communications (London, England),2021:

[9]Ciernikova Sona,Mego Michal,Chovanec Michal. Exploring the Potential Role of the Gut Microbiome in Chemotherapy-Induced Neurocognitive Disorders and Cardiovascular Toxicity.[J]. Cancers,2021,13(4):